Observatory: Viagra as Diet Pill?





New evidence suggests that the erectile-dysfunction drug Viagra might have another use: helping burn away excess fat.




The drug, generically known as sildenafil, helped convert undesirable white fat cells to energy-burning beige fat cells in laboratory mice, researchers at the University of Bonn in Germany report in The Journal of the Federation of American Societies for Experimental Biology.


It was already known that mice fed Viagra became less prone to obesity when fed a high-fat diet. What was not clear was why.


Dr. Alexander Pfeifer, director of the university’s Institute for Pharmacology and Toxicology, said he already had some clues: Viagra works by preventing the degradation of the intercellular messenger cGMP. Dr. Pfeifer has long been testing the effects of cGMP on fat cells.


So he fed the drug to mice for seven days and monitored their fat cells. As it turned out, the troublesome white fat cells, which are associated with human problems like the dreaded spare tire, were being converted to the beneficial type of fat cells at a higher rate than usual. Dr. Pfeifer called the results “very promising.”


Still, he cautions against taking the drug purely for dieting purposes. “The idea to have one pill and then obesity goes away, that is a dream, but not easy to come by,” he said. “What we are up to is basic research in mice. This pill is approved by the F.D.A. for a particular purpose for a reason.” 


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2012 stocks: How Illinois cos. fared









If you invested heavily in Illinois companies that provide consulting services, you had little reason to celebrate in 2012.

While the Standard & Poor's 500 index ended the year up 13 percent, most large businesses in the region that counsel other companies on how to improve their operations saw their stock prices drop.

Business support services was one of the few sectors getting clobbered in a 2012 Tribune ranking of Illinois and northwest Indiana stocks' performance.

Stock prices gained at about 70 percent of the 127 companies on the list, and about half outperformed the S&P 500. Bank owners such as Taylor Capital Group emerged from their 2011 doldrums, and Ulta Salon Cosmetics & Fragrance Inc. and Discover Financial Services marked their second consecutive year of soaring stock prices.

The year's biggest decliner, down 76 percent, was Groupon, as once-torrid revenue growth at the daily deals offerer started slowing.

Career Education was the second-worst performer; its stock fell 56 percent. The highly scrutinized for-profit school chain said it would close campuses and cut jobs amid sinking revenue and financial losses.

Sectors boosted by broad gains in 2012 included electrical parts and equipment, industrial machinery, and specialty chemicals.

Of seven Illinois banks on the list, all but one outperformed the S&P 500, with price appreciation of those six ranging from 16 to 86 percent.

In contrast, stocks of four of five professional services firms — Navigant Consulting, Huron Consulting Group, Heidrick & Struggles International and R.R. Donnelley & Sons — closed down 2 to 38 percent.

Each had its own set of issues.

Navigant's services, for example, include advising companies that face disputes, litigation and investigations, including government probes, as well as businesses that need help valuing potential mergers and acquisitions.

"You see fewer government investigations during an election year, as regulators are leaving their jobs, and they don't want to start new ones," said Tobey Sommer, a SunTrust Robinson Humphrey analyst. "Also, worries about the 'fiscal cliff' slowed M&A because CEOs didn't want to look foolish acquiring a company in September ahead of the fiscal cliff when they might have been able to buy it for 20 percent less in January had we gone off."

Meanwhile, Heidrick's troubles included a slowing market for executive searches. In early 2012, analysts expected Heidrick's annual earnings to be in the range of about $1.30 per share. It appears that it will earn closer to 57 cents a share.

Huron's earnings estimates during 2012 were also trimmed, to about $2.10 from about $2.40 a share as the timing of fee payments to its health care consulting business proved volatile.

"Its underlying demand is strong," but an increasing number of clients had signed contracts where a larger portion of revenue was contingent on the outcome of Huron's consulting work, said Randle Reece, analyst with Avondale Partners LLC. That made it harder for the company and the analysts who cover it to predict the timing of revenues, since they are deferred.

For investors interested in "Dumpster diving," Morningstar Inc. considers Exelon, WMS Industries and Caterpillar to be high quality yet undervalued this year, said Heather Brilliant, chief equities strategist.

Navigant is among the region's beaten-down stocks liked by stock research firm EVA Dimensions LLC. "Its fundamentals are improving, and it's really cheap," said EVA analyst Andrew Zamfotis.

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Fire at crowded nightclub kills at least 200 in Brazil










SANTA MARIA, Brazil (Reuters) - A nightclub fire killed at least 233 people in southern Brazil early on Sunday when a band's pyrotechnics show set the building ablaze and fleeing partygoers stampeded toward blocked and overcrowded exits in the ensuing panic, officials said.

The blaze in the university town of Santa Maria was ignited by sparks from pyrotechnics used by the band for visual effects. They set fire to soundproofing on the ceiling and the club rapidly filled with toxic smoke, local fire officials said.






Most of those who died were suffocated by fumes, fire brigade Sergeant Robson Muller told Reuters. Others were crushed in the stampede.

"Smoke filled the place instantly, the heat became unbearable," survivor Murilo Tiescher, a medical student, told GloboNews TV. "People could not find the only exit. They went to the toilet thinking it was the exit and many died there."

Fire officials said at least one exit was locked and that club bouncers, who at first thought those fleeing were trying to skip out on bar tabs, initially blocked patrons from leaving. The security staff relented only when they saw flames engulfing the ceiling.

The tragedy, in a packed venue in one of Brazil's most prosperous states, comes as the country scrambles to improve safety, security and logistical shortfalls ahead of the 2014 World Cup soccer tournament and the 2016 Olympics, both intended to showcase the economic advances and first-world ambitions of Latin America's largest nation.

In Santa Maria, a city of more than 275,000 people, rescue workers and weary officials wept alongside family and friends of the victims at a local gymnasium being used as a makeshift morgue.

"It's the saddest, saddest day of my life," said Neusa Soares, the mother of one of those killed, 22-year-old Viviane Tolio Soares. "I never thought I would have to live to see my girl go away."

President Dilma Rousseff cut short an official visit to Chile and flew to Santa Maria, where she wept as she spoke to relatives of the victims at the gym.

"All I can say at the moment is that my feelings are of deep sorrow," said Rousseff, who began her political career in Rio Grande do Sul, the state where the fire occurred.

News of the fire broke on Sunday morning, when local news broadcast images of shocked people outside the nightclub called Boate Kiss. Gradually, grisly details emerged.

"BARRIER OF THE DEAD"

"We ran into a barrier of the dead at the exit," Colonel Guido Pedroso de Melo, commander of the fire brigade in Rio Grande do Sul, said of the scene that firefighters found on arrival. "We had to clear a path to get to the rest of those that were inside."

Officials said more than 1,000 people may have been in the club, possibly exceeding its legal capacity. Though Internet postings about the venue suggested as many as 2,000 people at times have crammed into the club, Pedroso de Melo said no more than half that should have been inside.

He said the club was authorized to be open but its permit was in the process of being renewed.

However, Pedroso de Melo did point to several egregious safety violations - from the flare that went off during the show to the locked door that kept people from leaving.

The club's management said in a statement that its staff was trained and prepared to deal with any emergency. It said it would help authorities with their investigation.

When the fire began at about 2:30 a.m., many revelers were unable to find their way out in the chaos.

"It all happened so fast," survivor Taynne Vendrusculo told GloboNews TV. "Both the panic and the fire spread rapidly, in seconds."

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Abrams on ‘Star Wars’: ‘surreal’ and ‘exciting’






BEVERLY HILLS, Calif. (AP) — J.J. Abrams calls getting assigned to direct the seventh live-action “Star Wars” film “as surreal as it is exciting.”


The director-producer-writer spoke with a handful of media outlets on the red carpet before darting into the Producers Guild Awards on Saturday night. Abrams was there to accept the Norman Lear Achievement Award for such television works as “Felicity” (1998-2002), “Alias” (2001-2006), “Lost” (2004-2010), “Fringe” (2008-2013) as well as the current series “Person of Interest” and “Revolution.”






Abrams also is proving to be a go-to director of successful new films for long-established franchises, such as “Star Trek” and “Mission: Impossible.”


Last week, Lucasfilm officially announced Abrams’ hiring for “Star Wars: Episode VII,” which has a tentative release date of 2015. “Star Wars” creator George Lucas personally endorsed Abrams in a statement: “I’ve consistently been impressed with J.J. as a filmmaker and storyteller. He’s an ideal choice to direct the new Star Wars film and the legacy couldn’t be in better hands.”


As for Abrams’ plans for “Episode VII”?


“You know, obviously, it’s so early,” he replied. “I can just say what I want to do: I want to do the fans proud. I want to make sure the story is something that touches people. And we’re just getting started. I’m very excited.”


Entertainment News Headlines – Yahoo! News





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Brain Aging Linked to Sleep-Related Memory Decline


Scientists have known for decades that the ability to remember newly learned information declines with age, but it was not clear why. A new study may provide part of the answer.


The report, posted online on Sunday by the journal Nature Neuroscience, suggests that structural brain changes occurring naturally over time interfere with sleep quality, which in turn blunts the ability to store memories for the long term.


Previous research had found that the prefrontal cortex, the brain region behind the forehead, tends to lose volume with age, and that part of this region helps sustain quality sleep, which is critical to consolidating new memories. But the new experiment, led by researchers at the University of California, Berkeley, is the first to directly link structural changes with sleep-related memory problems.


The findings suggest that one way to slow memory decline in aging adults is to improve sleep, specifically the so-called slow-wave phase, which constitutes about a quarter of a normal night’s slumber.


Doctors cannot reverse structural changes that occur with age any more than they can turn back time. But at least two groups are experimenting with electrical stimulation as a way to improve deep sleep in older people. By placing electrodes on the scalp, scientists can run a low current across the prefrontal area, essentially mimicking the shape of clean, high-quality slow waves.


The result: improved memory, at least in some studies. “There are also a number of other ways you can improve sleep, including exercise,” said Ken Paller, a professor of psychology and the director of the cognitive neuroscience program at Northwestern University, who was not involved in the research.


Dr. Paller said that a whole array of changes occurred across the brain during aging and that sleep was only one factor affecting memory function.


But Dr. Paller said the study told “a convincing story, I think: that atrophy is related to slow-wave sleep, which we know is related to memory performance. So it’s a contributing factor.”


In the study, the research team took brain images from 19 people of retirement age and from 18 people in their early 20s. It found that a brain area called the medial prefrontal cortex, roughly behind the middle of the forehead, was about one-third smaller on average in the older group than in the younger one — a difference due to natural atrophy over time, previous research suggests.


Before bedtime, the team had the two groups study a long list of words paired with nonsense syllables, like “action-siblis” and “arm-reconver.” The team used the nonwords because one type of memory that declines with age is for new, previously unseen information.


After training on the pairs for half an hour or so, the participants took a test on some of them. The young group outscored the older group by about 25 percent.


Then everyone went to bed — and bigger differences emerged. For one, the older group got only about a quarter of the amount of high-quality slow-wave sleep that the younger group did, as measured by the shape and consistency of electrical waves on an electroencephalogram machine, or EEG. It is thought that the brain moves memories from temporary to longer-term storage during this deep sleep.


On a second test, given in the morning, the younger group outscored the older group by about 55 percent. The estimated amount of atrophy in each person roughly predicted the difference between his or her evening and morning scores, the study found. Even seniors who were very sharp at night showed declines after sleeping.


“The analysis showed that the differences were due not to changes in capacity for memories, but to differences in sleep quality,” said Bryce A. Mander, a postdoctoral fellow at Berkeley and the lead author of the study. His co-authors included researchers from the California Pacific Medical Center in San Francisco; the University of California, San Diego; and the Lawrence Berkeley National Laboratory.


The findings do not imply that medial prefrontal atrophy is the only age-related change causing memory problems, said Matthew P. Walker, a professor of psychology and neuroscience at Berkeley and a co-author of the study.


“Essentially, with age, you lose tissue in this prefrontal area,” Dr. Walker said. “You get less quality deep sleep, and have less opportunity to consolidate new memories.”


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2012 stock report: Pains and gains









If you invested heavily in Illinois companies that provide consulting services, you had little reason to celebrate in 2012.

While the Standard & Poor's 500 index ended the year up 13 percent, most large businesses in the region that counsel other companies on how to improve their operations saw their stock prices drop.

Business support services was one of the few sectors getting clobbered in a 2012 Tribune ranking of Illinois and northwest Indiana stocks' performance.

Stock prices gained at about 70 percent of the 127 companies on the list, and about half outperformed the S&P 500. Bank owners such as Taylor Capital Group emerged from their 2011 doldrums, and Ulta Salon Cosmetics & Fragrance Inc. and Discover Financial Services marked their second consecutive year of soaring stock prices.

The year's biggest decliner, down 76 percent, was Groupon, as once-torrid revenue growth at the daily deals offerer started slowing.

Career Education was the second-worst performer; its stock fell 56 percent. The highly scrutinized for-profit school chain said it would close campuses and cut jobs amid sinking revenue and financial losses.

Sectors boosted by broad gains in 2012 included electrical parts and equipment, industrial machinery, and specialty chemicals.

Of seven Illinois banks on the list, all but one outperformed the S&P 500, with price appreciation of those six ranging from 16 to 86 percent.

In contrast, stocks of four of five professional services firms — Navigant Consulting, Huron Consulting Group, Heidrick & Struggles International and R.R. Donnelley & Sons — closed down 2 to 38 percent.

Each had its own set of issues.

Navigant's services, for example, include advising companies that face disputes, litigation and investigations, including government probes, as well as businesses that need help valuing potential mergers and acquisitions.

"You see fewer government investigations during an election year, as regulators are leaving their jobs, and they don't want to start new ones," said Tobey Sommer, a SunTrust Robinson Humphrey analyst. "Also, worries about the 'fiscal cliff' slowed M&A because CEOs didn't want to look foolish acquiring a company in September ahead of the fiscal cliff when they might have been able to buy it for 20 percent less in January had we gone off."

Meanwhile, Heidrick's troubles included a slowing market for executive searches. In early 2012, analysts expected Heidrick's annual earnings to be in the range of about $1.30 per share. It appears that it will earn closer to 57 cents a share.

Huron's earnings estimates during 2012 were also trimmed, to about $2.10 from about $2.40 a share as the timing of fee payments to its health care consulting business proved volatile.

"Its underlying demand is strong," but an increasing number of clients had signed contracts where a larger portion of revenue was contingent on the outcome of Huron's consulting work, said Randle Reece, analyst with Avondale Partners LLC. That made it harder for the company and the analysts who cover it to predict the timing of revenues, since they are deferred.

For investors interested in "Dumpster diving," Morningstar Inc. considers Exelon, WMS Industries and Caterpillar to be high quality yet undervalued this year, said Heather Brilliant, chief equities strategist.

Navigant is among the region's beaten-down stocks liked by stock research firm EVA Dimensions LLC. "Its fundamentals are improving, and it's really cheap," said EVA analyst Andrew Zamfotis.

Best of the best

Here are the top three stock gainers of 2012:

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Family friend: Man 4th sibling to be killed by gunfire

At the north end of the 1100 block of South Mozart Street in the Lawndale neighborhood, two people were shot. One also died there, police said. (Posted Jan. 26th, 2013)









A man slain on the West Side early this morning had two brothers and a sister who also were fatally gunned down in the city, according to a close family friend.


"He was the last one," said Laverne Smith, 30, who said his mother no longer has any children. "I know she's hurting."


Smith said it's unthinkable this could have happened again to the family.








"It's ridiculous," Smith said. "We need to get the guns off the street and build a good life for our babies. We need to really get together and stop fighting."


Smith heard loud gunfire about 2 a.m. and ran outside in the 1100 block of South Mozart Street to find her close friend Ronnie Chambers shot in the head. He died in her arms.


"All his siblings passed a long time ago," Smith said. "It was a hysterical thing."


Smith said she also knew Ronnie Chambers' sister, LaToya Chambers, and had grown up with them in the Cabrini Green neighborhood on the Near North Side. LaToya was a classmate of hers, about two years ahead, at the Edward Jenner school.


LaToya was killed at age 15 on April 26, 2000. Her brothers Carlos and Jerome also were gunshot victims, Carlos at age 18 shortly after Thanksgiving in 1995 and Jerome at age 23 on July 26, 2000.


Chambers' mother Shirley told the Tribune's Dawn Turner Trice in 2000 that "I have one child left, and I'm afraid that [the killing] won't stop until he's gone too."


According to that 2000 story, Ronnie has these tattoos on his forearms to remind him of his dead siblings: A crucifix with a ribbon draped across it commemorates Carlos; a tombstone with a crucifix and blood says R.I.P. for Jerome; and another tombstone with a cross is for LaToya.


"They say you can't outrun death, but I can try to dodge it," Ronnie said then. "I don't even try to live day by day anymore; it's more like second by second."


"He was my everything," Smith said of Ronnie's death. "I lost a part of me."


"Nothing that anyone can say can make me feel better," said Smith, who said Chambers was recently on the Ricki Lake show and was trying to help an aspiring rapper, YK.


Smith said Ronnie, whose nickname was "Scooby," had been "trying to change his life."


Ronnie Chambers had just returned from a promotion or listening party for YK when the shooting occurred.


Smith stood crying at one end of a vacant lot in the Lawndale neighborhood on the West Side early this morning while Chambers lay covered by a white sheet behind a maroon van at the other end.

Chambers, 33, of Chicago, had been in the driver's seat of the van, which had just arrived in the 1100 block of South Mozart Street when one person, probably two, opened fire, police said. Chambers was identified by family members at the scene and later by police. 


Smith wore a pink blood-stained shirt under a pink jacket, white pants dotted with drops of blood, and pink sandals. She paced the crime scene, at the north end of Mozart Drive where it ends at Fillmore Street, letting out occasional screams and leaning on her friend for support.

"I held him, they had to pry me from him," she said, crying. "He was breathing, gasping."


At least one other man, 21, was inside the van when the shooting started, police said. He had jumped from the front passenger seat to the back, quick thinking that police said probably saved his life. He was wounded in the thigh and taken to Mount Sinai Hospital. Police did not say how many people were inside the van. They also did not say exactly how many shooters there were, but did say seven shots were fired.


The shooting happened across the street from Safer Foundation North Lawndale, an Illinois Department of Corrections transitional facility for adults with criminal records, and half a block west of a fire station.


Family and friends, none of whom wanted to give their names, circled the north end of the scene, marked by yellow tape hung around trees, light poles and cop cars.


A young man at the scene who refused to give his name but said he saw the shooting called the gun used a "big boy."


"Look at that (bullet) hole," the young man said, motioning to the passenger side door on the van. "That's a full nickel."


An east-facing car sat abandoned in the T intersection formed by Mozart and Fillmore. Police weren't sure whether the people who abandoned the car were involved in the shooting or freaked out and fled the scene. Police found casings from two weapons – one a rifle – whose bullets had entered the van from both sides.


"He was gangsta with his (expletive)," the man said of the individual or individuals who did the shooting. "He knew what he was doing."


Despite his apparent proximity to the attack, he explained to a detective that he could not help police do their jobs. He later complained to a supervisor about their response time – he said 27 minutes but police said 3. Police said that they received one 911 call about shots being fired in the area.


A 16-year-old boy who said he was with the victims when the shooting happened wandered around the lot, looking toward the ground most of the time. He looked emotionally spent after being held by police for a short time at the scene.


"I just want to go home," he said, though he had no ride home. "It just happened so fast. I'm tired of explaining myself."


In another fatal overnight shooting, three men were shot about 4 a.m. outside of a diner at the corner of Wallace Street and Pershing Road in the Bridgeport neighborhood on the South Side, police said. Two men died at the scene.


pnickeas@tribune.com

Twitter: @PeterNickeas





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Smartphone 4Q sales rise 36 pct led by Samsung






SAN FRANCISCO (AP) — Smartphone shipments rose 36 percent worldwide in the fourth quarter as the sleek devices supplanted personal computers and other gadgets on holiday shopping lists, according to a report released Friday.


The findings from the research firm International Data Corp. are the latest sign of the technology upheaval being wrought by the growing popularity of smartphones that can perform a wide variety of tasks, including surfing the Web and taking high-quality photos.






Companies whose fortunes are tied to the PC industry have been particularly hard hit by the shift to smartphones and tablet computers.


While some smartphone models were in short supply during the holiday season, fourth-quarter PC shipments fell by 6 percent from the previous year, according to another IDC report released earlier this month.


IDC estimates 219 million smartphones were shipped during the final three months of last year. That compares with nearly 161 million in the same 2011 period. Smartphones accounted for about 45 percent of all mobile phone shipments in the fourth quarter, the highest percentage recorded by IDC.


Samsung Electronics Co. retained its bragging rights as the smartphone leader, shipping nearly 64 million devices for a 29 percent share of the global market.


Apple Inc. ranked second with nearly 48 million iPhones shipped during the fourth quarter, translating into a market share of 22 percent.


For all of 2012, IDC estimated nearly 713 million smartphones were shipped worldwide, a 44 percent increase from the previous year. Meanwhile, annual PC shipments fell 3 percent from 2011, IDC said. It was the first annual decline since 2001.


Entering 2012, Apple held a slight edge over Samsung in the smartphone market. But Samsung sprinted past Apple during the year as it introduced an array of models, most of which run on Google Inc.‘s free Android software. Samsung’s top-selling line, the Galaxy, boasts larger display screens than the iPhone and other features.


Apple alleges Samsung’s devices illegally ripped off the iPhone’s innovations. After a high-profile trial in federal court, a jury in San Jose, Calif. sided with some of the patent infringement claims last August and decided Samsung should pay more than $ 1 billion in damages. Samsung has been trying to overturn the verdict.


Lower-priced smartphones from Samsung and other device makers also have hurt Apple, whose slowing iPhone growth has contributed to a $ 250 billion decline in its market value since its stock price peaked in late September.


IDC says Huawei Technologies Ltd.‘s emphasis on less expensive handsets helped it become the third largest smartphone maker with a market share of 5 percent at the end of the fourth quarter.


Gadgets News Headlines – Yahoo! News





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“Office” vets Craig Robinson, Greg Daniels sell pilot to NBC






NEW YORK (TheWrap.com) – A few veterans of “The Office” have lined up their next job: Executive producer Greg Daniels, star Craig Robinson and writer-producer Owen Ellickson have sold an untitled pilot to NBC in which Robinson would play a musician who becomes a music teacher.


Tracy Katsky, Howard Klein and Mark Schulman will also executive produce the single-camera comedy, which Robinson will produce.






The story revolves around Robinson’s character adjusting to precocious kids, teaching politics, and the temptations of single moms.


On Friday, NBC ordered another comedy executive produced by Daniels, Katsky, and Klein. The untitled sitcom from writer/executive producer Robert Padnick focuses on a group of friends struggling with dating in their twenties.


“The Office” is winding down its final season.


TV News Headlines – Yahoo! News





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Religious Groups and Employers Battle Contraception Mandate


Shawn Thew/European Pressphoto Agency


President Obama, with his health secretary, Kathleen Sebelius, offering a compromise on the contraception mandate last year.







In a flood of lawsuits, Roman Catholics, evangelicals and Mennonites are challenging a provision in the new health care law that requires employers to cover birth control in employee health plans — a high-stakes clash between religious freedom and health care access that appears headed to the Supreme Court.




In recent months, federal courts have seen dozens of lawsuits brought not only by religious institutions like Catholic dioceses but also by private employers ranging from a pizza mogul to produce transporters who say the government is forcing them to violate core tenets of their faith. Some have been turned away by judges convinced that access to contraception is a vital health need and a compelling state interest. Others have been told that their beliefs appear to outweigh any state interest and that they may hold off complying with the law until their cases have been judged. New suits are filed nearly weekly.


“This is highly likely to end up at the Supreme Court,” said Douglas Laycock, a law professor at the University of Virginia and one of the country’s top scholars on church-state conflicts. “There are so many cases, and we are already getting strong disagreements among the circuit courts.”


President Obama’s health care law, known as the Affordable Care Act, was the most fought-over piece of legislation in his first term and was the focus of a highly contentious Supreme Court decision last year that found it to be constitutional.


But a provision requiring the full coverage of contraception remains a matter of fierce controversy. The law says that companies must fully cover all “contraceptive methods and sterilization procedures” approved by the Food and Drug Administration, including “morning-after pills” and intrauterine devices whose effects some contend are akin to abortion.


As applied by the Health and Human Services Department, the law offers an exemption for “religious employers,” meaning those who meet a four-part test: that their purpose is to inculcate religious values, that they primarily employ and serve people who share their religious tenets, and that they are nonprofit groups under federal tax law.


But many institutions, including religious schools and colleges, do not meet those criteria because they employ and teach members of other religions and have a broader purpose than inculcating religious values.


“We represent a Catholic college founded by Benedictine monks,” said Kyle Duncan, general counsel of the Becket Fund for Religious Liberty, which has brought a number of the cases to court. “They don’t qualify as a house of worship and don’t turn away people in hiring or as students because they are not Catholic.”


In that case, involving Belmont Abbey College in North Carolina, a federal appeals court panel in Washington told the college last month that it could hold off on complying with the law while the federal government works on a promised exemption for religiously-affiliated institutions. The court told the government that it wanted an update by mid-February.


Defenders of the provision say employers may not be permitted to impose their views on employees, especially when something so central as health care is concerned.


“Ninety-nine percent of women use contraceptives at some time in their lives,” said Judy Waxman, a vice president of the National Women’s Law Center, which filed a brief supporting the government in one of the cases. “There is a strong and legitimate government interest because it affects the health of women and babies.”


She added, referring to the Centers for Disease Control and Prevention, “Contraception was declared by the C.D.C. to be one of the 10 greatest public health achievements of the 20th century.”


Officials at the Justice Department and the Health and Human Services Department declined to comment, saying the cases were pending.


A compromise for religious institutions may be worked out. The government hopes that by placing the burden on insurance companies rather than on the organizations, the objections will be overcome. Even more challenging cases involve private companies run by people who reject all or many forms of contraception.


The Alliance Defending Freedom — like Becket, a conservative group — has brought a case on behalf of Hercules Industries, a company in Denver that makes sheet metal products. It was granted an injunction by a judge in Colorado who said the religious values of the family owners were infringed by the law.


“Two-thirds of the cases have had injunctions against Obamacare, and most are headed to courts of appeals,” said Matt Bowman, senior legal counsel for the alliance. “It is clear that a substantial number of these cases will vindicate religious freedom over Obamacare. But it seems likely that the Supreme Court will ultimately resolve the dispute.”


The timing of these cases remains in flux. Half a dozen will probably be argued by this summer, perhaps in time for inclusion on the Supreme Court’s docket next term. So far, two- and three-judge panels on four federal appeals courts have weighed in, granting some injunctions while denying others.


One of the biggest cases involves Hobby Lobby, which started as a picture framing shop in an Oklahoma City garage with $600 and is now one of the country’s largest arts and crafts retailers, with more than 500 stores in 41 states.


David Green, the company’s founder, is an evangelical Christian who says he runs his company on biblical principles, including closing on Sunday so employees can be with their families, paying nearly double the minimum wage and providing employees with comprehensive health insurance.


Mr. Green does not object to covering contraception but considers morning-after pills to be abortion-inducing and therefore wrong.


“Our family is now being forced to choose between following the laws of the land that we love or maintaining the religious beliefs that have made our business successful and have supported our family and thousands of our employees and their families,” Mr. Green said in a statement. “We simply cannot abandon our religious beliefs to comply with this mandate.”


The United States Court of Appeals for the 10th Circuit last month turned down his family’s request for a preliminary injunction, but the company has found a legal way to delay compliance for some months.


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